Method of preparing a sample for analysis by laser desorption io

Details Method of preparing a sample for analysis by laser desorption io Method of preparing a sample for analysis by laser desorption io

1995-09-21

1997-07-01

Spiegel, Carol A.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436526, 436527, 436531, 436810, 436 8, 435 4, 435 71, 435970, 427 211, 250288, G01N 3353

Patent

active

056438001

ABSTRACT:
The present invention is a sample preparation system and method that can be used with all types of analyte materials, that produces homogeneously deposited crystals across a sample surface, and that lends itself to automation. In this system and method, analyte crystallization is caused by lyophilization. A homogeneous analyte/solvent mixture is placed on a sample surface. The mixture is frozen, then the solvent is sublimated through the application of a vacuum. A homogenous distribution of analyte crystals across the sample surface results.

REFERENCES:
patent: 4461829 (1984-07-01), Greenquist
patent: 4531373 (1985-07-01), Rubinsky
patent: 4584781 (1986-04-01), Parkinson et al.
patent: 5015845 (1991-05-01), Allen et al.
patent: 5024830 (1991-06-01), Linner et al.
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5171989 (1992-12-01), Williams
patent: 5245185 (1993-09-01), Busch et al.
patent: 5256241 (1993-10-01), Noever
patent: 5281538 (1994-01-01), Cottrell et al.
"Device for Controlling Crystallization of Protein," NASA Tech Briefs, vol. 17, No. 9, Sep. 1993, pp. 92-93.
Preston et al, "Reproducibility and Quantitation of Matrix-assisted Laser Desorption Ionization Mass Spectrometry . . . " Biol. Mass Spec. vol. 22 (1993), pp. 544-550.
Vorm et al, "Improved Resolution and Very High Sensitivity in MALDI TOF . . . " Anal. Chem. vol. 66 (1994), pp. 3281-3287.

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