Method of preparing a rapidly dissolving powder of sterile cryst

Details Method of preparing a rapidly dissolving powder of sterile cryst Method of preparing a rapidly dissolving powder of sterile cryst

1977-12-14

1979-04-03

Camby, John J.

Drying and gas or vapor contact with solids

Apparatus

With means to treat gas or vapor

F26B 506

Patent

active

041469712

ABSTRACT:
Sterile, essentially crystalline cefazolin sodium for parenteral administration is prepared by a freeze-drying process wherein a C.sub.1 -C.sub.3 alcohol-water solution of cefazolin sodium containing about 10 percent by volume of the C.sub.1 -C.sub.3 alcohol is chilled slowly from room temperature to about -10.degree. C. over a 3-12 hour period and then rapidly cooled to -30.degree. to about -40.degree. C. and held for 1-2 hours before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in acceptable pharmaceutical diluents.

REFERENCES:
patent: 3449885 (1969-06-01), Starkey
patent: 4029655 (1977-06-01), Cise

Affiliated with

Also associated with

Rating

Method of preparing a rapidly dissolving powder of sterile cryst does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing a rapidly dissolving powder of sterile cryst, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing a rapidly dissolving powder of sterile cryst will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1741276