Method of preparing a rapidly dissolving powder of crystalline c

Details Method of preparing a rapidly dissolving powder of crystalline c Method of preparing a rapidly dissolving powder of crystalline c

1977-11-03

1979-01-02

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50102

Patent

active

041328485

ABSTRACT:
Essentially crystalline cephalothin sodium for parenteral administration is prepared by a freeze-drying process wherein a (C.sub.1 -C.sub.3 alcohol or acetone)-water solution of cephalothin sodium containing from about 2 to about 10 percent of C.sub.1 -C.sub.3 alcohol or acetone by volume is chilled from room temperature to -20.degree. C., or below, preferably about -40.degree. C. over a 1-3 hour period and then warmed to from about -3.degree. C. to about -10.degree. C. and held for 3 hours or more, then cooled to -20.degree. C., or below, preferably about -40.degree. C., before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in acceptable pharmaceutical diluents. Alternatively, from about 2 to about 5 percent by weight of sodium bicarbonate, related to the amount of cephalothin sodium present, is added to the solution before freeze-drying.

REFERENCES:
patent: 4028355 (1977-06-01), Blackburn
patent: 4029655 (1977-06-01), Cise
patent: 4061853 (1977-12-01), Urech

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