Method of preparing a polymorph of terfenadine

Details Method of preparing a polymorph of terfenadine Method of preparing a polymorph of terfenadine

1992-12-31

1994-09-13

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21122

Patent

active

053470060

ABSTRACT:
The invention relates to a method for preparing HMP terfenadine comprising the steps of reacting terfenadone free-base with sodium borohydride to yield mixed polymorph terfenadine and crystallizing said mixed polymorph terfenadine from a seeded ester or ketone solvent system to yield substantially pure HMP terfenadine.

REFERENCES:
patent: 4742175 (1988-05-01), Fawcett et al.
Carr et al., Arzneim-Forsch/Drug Res. 32(II) 9A, 1157-9 (1982).

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