Method of preparing a multiphase composition

Compositions – Preservative agents – Anti-corrosion

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2522997, 252308, 252309, 2523151, 2523153, 2523154, 424 7803, 514847, 514937, 514944, A61K 3178, A61K 31785, B01J 1300, C09K 1936

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053043340

ABSTRACT:
The instant invention relates to methods of preparing and stabilizing complex multiphase compositions that include distinct phases of water, gel, liquid crystal or oil and perfluoropolyether dispersed in a continuous phase of a silicone fluid. In particular, the present invention relates to a method of preparing a stable multiphase composition comprising the steps of mixing an aqueous solution of a water-soluble polymeric emulsifier, a silicone-based emulsifier and an oleophobic, hydrophobic silicone fluid in amounts effective to form a stable water-in-silicone emulsion; mixing the water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing, water-soluble polymer, the emulsion and gel being combined in amounts effective to form a dispersion in which the gel is dispersed in the emulsion; and adding to the dispersion an oil or a thermotropic liquid crystal and a perfluoropolyether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, oil or liquid crystal and perfluoropolyether.

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A. Bevacqua, K. Lahanas; I. Cohen; G. Cioca; Liquid Crystals in Multiple Emulsions; Cosmetics & Toiletries; vol. 106, May 1991; pp. 53-56.

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