Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-09-27
1991-08-20
Rosen, Sam
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530412, 530416, C07K 300
Patent
active
050415379
ABSTRACT:
To provide a simple method of preparing biologically active transferrin that can be employed on an industrial scale and that will result in extremely pure and natural transferrin containing no viruses and appropriate for both in-vitro and in-vivo applications, the .gamma.-globulins are precipitated from the fraction containing the transferrin, the precipitant is removed from the residual liquid by ultrafiltration or gel filtration, the liquid is adjusted to a prescribed ionic concentration and protein concentration and (a) treated with .beta.-propiolactone and the solution is subjected to ultraviolet radiation or (b) treated with specific detergents and subjected to ion-exchange chromatography, and the transferrin is concentrated and filtered sterile.
REFERENCES:
patent: 3959249 (1976-05-01), Antonini
patent: 4540573 (1985-09-01), Neurath et al.
patent: 4841026 (1989-06-01), Van Beveren et al.
Deutsche Medizinische Wochenschrift, 110, (1985), pp. 55-63.
Reviews of Infectious Diseases, 5, (1983), No. 1, pp. 92-107.
The Journal of Biological Chemistry, 242, (1967), No. 10, pp. 2507-2513.
Vox Sanguinis, 6, (1961), pp. 24-52.
Vox Sanguinis, 5, (1960), pp. 403-415.
Journal of Immunological Methods, 65, (1983), pp. 55-63.
Methods in Enzymology, LVIII, (1979), pp. 44-93.
Bethke Ulf
Kloft Michael
Kothe Norbert
Moller Wolfgang
Rudnick Dieter
Biotest Pharma GmbH
Rosen Sam
LandOfFree
Method of preparing a high-purity, virus safe, biologically acti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of preparing a high-purity, virus safe, biologically acti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing a high-purity, virus safe, biologically acti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1008888