Method of preparing a guanosine-group compound and an...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

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C435S193000, C435S252500, C435S087000, C435S089000, C536S124000, C536S027100, C536S027300

Reexamination Certificate

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07148042

ABSTRACT:
A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

REFERENCES:
patent: 0 411 158 (1990-02-01), None
patent: 0 896 065 (1999-02-01), None
patent: 05 170 767 (1993-07-01), None
Palladino et al., J. Am. chem. Soc., 1986 108(19), 6066-6068.
Chemical Abstracts Service, Columbus, Ohio, US, XP-002191262, abstract of Chung et al.,Carcinogenesis6(11), 1671-3 (1985).
Paladino et al.,J. Am. chem., Soc., 1986 108(19), 6066-6068.

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