Drying and gas or vapor contact with solids – Apparatus – With means to treat gas or vapor
Patent
1990-04-16
1991-09-03
Yuen, Henry C.
Drying and gas or vapor contact with solids
Apparatus
With means to treat gas or vapor
34 15, 34 92, F26B 506
Patent
active
050440918
ABSTRACT:
In a freeze-drying method for producing a dried pharmaceutical compound or preparation, a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains said pharmaceutical compound of preparation dissolved or suspended therein. The other liquid or liquids may be pure solvent (generally water) or may contain one or more other substances.
REFERENCES:
patent: 4430807 (1984-02-01), Davis et al.
patent: 4433558 (1984-02-01), Cheng et al.
patent: 4470202 (1984-09-01), Buxton et al.
Williams et al., "The Lyophilization of Pharmaceuticals: A Literature Review", J. Parenteral Science and Technology, 38, pp. 48-59 (1976).
Koyama et al., "Effect of Solvent Addition and Thermal Treatment on Freeze Drying of Cefazolin Sodium", J. Parenteral Science and Technology, 42, pp. 47-52 (1988).
Journal of the Research Society of Freezing and Drying, 22, pp. 48-55 (1976).
Farumashi, 5, pp. 99-102, vol. 5, No. 2, Feb. 1969.
Hashi Kunio
Kusai Akira
Shiokari Takashi
Ueda Seigo
Sankyo Company Limited
Yuen Henry C.
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