Method of preparing a forskohlin composition from forskohlin ext

Details Method of preparing a forskohlin composition from forskohlin ext Method of preparing a forskohlin composition from forskohlin ext

1997-02-27

1998-09-08

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3135

Patent

active

058045961

ABSTRACT:
A method of promoting lean body mass in an individual is disclosed, comprising administering to the individual a lean body mass promoting effective amount of forskohlin. A method of treating a mood disorder is also disclosed, comprising administering to a patient in need thereof a mood disorder treating effective amount of forskohlin. Compositions suitable for promoting lean body mass and/or treating a mood disorder are also disclosed, the composition comprising about 1 to about 40% forskohlin in combination with at least one physiologically acceptable carrier or excipient. A method of preparing a forskohlin composition from a forskohlin extract of Coleus Forskoli plant is further disclosed, as well as a forskohlin composition prepared by the method.

REFERENCES:
Hoffman, et al., Horm. metabol. Res., 19 (1987) pp. 358-360, "Stimulation and Inhibition of Lipolysis in Isolated Rat Adipocytes: Evidence for Age-Related Changes in Responses . . . ".
Allen, et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 238, Not. 2, pp. 659-664, "Relationships between cyclic AMP Levels and Lipolysis in Fat Cells After . . . ".
Allen, et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 244, No. 3, pp. 852-858, "Quantitative Differences in the Cyclic AMP-Lipolysis Relationships for . . . ".
Wachtel, et al, Psychopharmacology (1986) 90 pp. 430-435, "Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram".

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