Method of preparing a fibrinogen concentrate from blood plasma

Details Method of preparing a fibrinogen concentrate from blood plasma Method of preparing a fibrinogen concentrate from blood plasma

1992-07-17

1994-06-14

Wityshyn, Michael G.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530380, 424530, A61K 3514

Patent

active

053211260

ABSTRACT:
A method of preparing fibrinogen concentrate from blood plasma by cooling said plasma from a temperature above 0.degree. C. to a first temperature between -10.degree. C. and -40.degree. C., thawing the solid material thus obtained to a temperature near the freezing point of water and subsequently physically separating the solid matter and the liquid main fraction of the plasma, viz. water, whereby the thawing is effected in steps from the first temperature to a conditioning temperature between -5.degree. C. and -1.degree. C., after which the size of the solid material is reduced and the reduced material is brought to a temperature at which the main fraction of the plasma, viz. water, becomes liquid and the solubility of fibrinogen in said fluid is as low as possible, after which fluid is separated from the fibrinogen concentrate. The invention also relates to a device for carrying out this method.

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Dresdale et al. (1985) Surgery 97(6): 750-755, 1985.
Spotnitz et al. (1987), The American Surgeon 53(8): 460-462.

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