Method of preparing a controlled-release pharmaceutical preparat

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 25, 424 36, 424178, 4272133, A61K 952, B01J 1302

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active

RE0316091

ABSTRACT:
A method of preparing a controlled-release pharmaceutical compound for oral administration, which pharmaceutical compound is subject to enzymatic hydrolysis on oral administration, which method comprises encapsulating the pharmaceutical compound with a synthetic phosphatidyl compound having a modified polarhead moiety which increases the resistance of the phosphatidyl compound to phospholipase C hydrolysis.

REFERENCES:
patent: Re30748 (1981-09-01), Sears
patent: 4016100 (1977-04-01), Suzuki et al.
patent: 4159988 (1979-07-01), Eibl et al.
Gregoriadis: "The Carrier Potential of Liposomes in Biology and Medicine," New England J. Med. 295, 704-710, Sep. 23, 1976.

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