Method of preparing a composite bone graft

Details Method of preparing a composite bone graft Method of preparing a composite bone graft

1996-07-03

1998-10-20

Weiss, John G.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

623 11, A61F 228, A61F 202

Patent

active

058240845

ABSTRACT:
The present invention provides a new and improved method for preparing a composite bone graft. The method includes providing a bone marrow aspirate suspension and passing the bone marrow aspirate suspension through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. Because the method is preferably performed intraoperatively it reduces the number of occasions the graftee must undergo invasive procedures. The invention also relates to an improved composite bone graft prepared according to the present method. The improved composite graft includes an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. The present invention also relates to a kit including the apparatus used for preparing the composite bone graft.

REFERENCES:
patent: 4608199 (1986-08-01), Caplan et al.
patent: 4609551 (1986-09-01), Caplan et al.
patent: 5197985 (1993-03-01), Caplan et al.
patent: 5226914 (1993-07-01), Caplan et al.
patent: 5486359 (1996-01-01), Caplan et al.
"The Origin of Bone Formed in Composite Grafts of Porous Calcium Phosphate Ceramic Loaded with Marrow Cells", by J. Goshima et al., Clinical Orthopoedics and Related Research, vol. 269, pp. 274-283, 1991.

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