Method of preparing a chlorinated, brominated, radio-brominated,

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

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424 11, 546345, 558388, 562456, 562449, 562574, 570174, 252645, C07D24314, C07D 3336, C07B 2300, C07C 5758, C07C 8728

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049422316

ABSTRACT:
The invention relates to a method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound, in which the (hetero)aromatic nucleus optionally comprises one or more additional substituents, by reacting the corresponding halogenated or diazonium-substituted compound in the presence of a water-soluble acid and of copper ions as a catalyst with a likewise water-soluble chloride, bromide radiobromide, iodide or radio-iodide, in which the reaction is carried out in the presence of one or more reduction agents, which are stable in acid medium, in a quantity exceeding the quantity of catalyst. The invention also relates to a composition suitable for diagnostic examination and to a kit for the preparation thereof. The invention further relates to a method and an equipment for the preparation of said composition.

REFERENCES:
patent: 3859429 (1975-01-01), Elias
patent: 4298591 (1981-11-01), O'Brien et al.

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