Method of preparing 7,8-difluoro-2,3-dihydro-3-methyl-4H-1, 4-be

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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564442, C07D26536

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active

056440561

ABSTRACT:
A method of preparing 7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4 benzoxazine. The method includes the steps of reacting 2,3,4-trifluoroaniline or trifluoronitrobenzene with hydroxyacetone or a derivative thereof under reducing conditions to yield N-(3-hydroxy-2-propyl)-2,3,4 trifluoroaniline. The N-(3-hydroxy-2-propyl)-2,3,4-trifluoroaniline is treated with a base to yield the above-mentioned benzoxazine.

REFERENCES:
patent: 5136059 (1992-08-01), Fujiwara et al.

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