Method of preparing 51,N6-disubstituted adenosines from inosines

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 23, 536 24, 536 27, 536 28, C07H 19167, C07H 1920

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049621947

ABSTRACT:
A processing for preparing 5'-N,6-disubstituted adenosines from inosines. The adenosines have usefulness as neuroleptics, analgesics, cardiotonics, antihypertensives, antilipolytics, antihyperlipaemics, antiinflammatory agents, antithrombotic or antiembolic agents.

REFERENCES:
patent: 3282921 (1966-11-01), Verheyden et al.
patent: 4373097 (1983-02-01), Stramentinoli et al.
Feiser & Fieser, Reagents for Organic Synthesis, vol. 1, John Wiley & Sons, Inc., New York, N.Y., 1967, see pp. 1247-1249.
Fieser & Fieser, Reagents for Organic Synthesis, vol. 6, John Wiley & Sons, Inc., New York, NY, 1977, see pp. 645-648.
Acheson, An Introduction to the Chemistry of Heterocyclic Compounds, Wiley-Interscience, New York, NY, 1967, pp. 211, 212, 338, 339.
Goodman (I), "Chemical Synthesis and Transformations of Nucleosides", in Basic Principles of Nucleic Acid Chemistry by Ts'O, Academic Press, New York, NY, 1974, pp. 151, 154, 155 & 159.
Goodman (II), "Chemical Synthesis and Transformations of Nucleosides", in Basic Principles of Nucleic Acid Chemistry by Ts'O, Academic Press, New York, NY 1974, see pp. 136-138.

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