Method of preparing 5-amino-3-substituted-pyrazole

Details Method of preparing 5-amino-3-substituted-pyrazole Method of preparing 5-amino-3-substituted-pyrazole

1992-02-26

1994-01-04

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548247, 5483657, 5483061, C07D23138

Patent

active

052761584

ABSTRACT:
A process of preparing a 5-amino-3-substituted pyrazole of formula (I) ##STR1## wherein R is an optionally substituted alkyl group or an optionally substituted aryl group, said process comprising reacting a compound of formula (III) ##STR2## with H.sub.2 NNH.sub.2 to obtain the compound of formula (I). The compound of formula (III) can be obtained by reacting a ketone of the formula R-CO-CH.sub.3 with DMF--acetal (HC(OCH.sub.3).sub.2 N(CH.sub.3).sub.2) followed by subsequent reaction with NH.sub.2 OH.sup..cndot. HCl.

REFERENCES:
patent: 4540654 (1985-09-01), Sato et al.
patent: 4924002 (1990-05-01), Kostlan
Wiley, Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles and Condensed Rings, (1967), p. 56.
Lin et al, Journal of Heterocyclic Chemistry, vol. 14 (1977) pp. 345-347.
Katritzky, Comprehensive Heterocyclic Chemistry, vol. 6 (1986) pp. 62-63.

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