Method of preparing 4-methyl-5-hydroxymethyl-imidazole

Details Method of preparing 4-methyl-5-hydroxymethyl-imidazole Method of preparing 4-methyl-5-hydroxymethyl-imidazole

1979-01-25

1980-02-19

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23364

Patent

active

041895916

ABSTRACT:
The yield of 4-methyl-5-hydroxymethyl-imidazole from the known reaction between formaldehyde and 4-methyl-imidazole can be increased greatly if the reaction is performed in a concentrated aqueous medium at pH 11-13.5, preferably 12-13.5, at a temperature of 20.degree.-60.degree. C., preferably 30.degree.-40.degree. C., with an amount of formaldehyde not exceeding 1.5 mole per mole of 4-methyl-imidazole.

REFERENCES:
patent: 4104473 (1978-08-01), Sawa et al.
Godefroi et al., Recueil des travaux chimiques de pays/bas 1972, vol. 91, pp. 1383-1392.
Grindley et al., J. Chem. Soc. (London) 1927, pp. 3128-3136.
Hofmann, Imidazole and Its Derivatives Part I, pp. 99-100, N.Y., Interscience, 1953.
Masui et al., Chem. Pharm. Bull. 1974, vol. 22, pp. 2359-2364.
Windaus Berichte (Deutsche Chem. Gesellschaft) 1909, vol. 42, pp. 758-763.

Affiliated with

Also associated with

Rating

Method of preparing 4-methyl-5-hydroxymethyl-imidazole does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing 4-methyl-5-hydroxymethyl-imidazole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing 4-methyl-5-hydroxymethyl-imidazole will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-654207