Method of preparing 2-chloro-pyridinemethanol

Details Method of preparing 2-chloro-pyridinemethanol Method of preparing 2-chloro-pyridinemethanol

1994-06-01

1995-08-08

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21330

Patent

active

054400473

ABSTRACT:
The invention relates to a method of preparing 2-chloro-pyridinemethanol represented by the following formula (1). The method includes the steps of: (a) reacting 2-chloro-monochloromethylpyridine with an alkali metal salt of a carboxylic acid and/or a hydrate of the alkali metal salt so as to form an ester derivative; and (b) hydrolyzing the ester derivative so as to form the 2-chloro-pyridinemethanol. ##STR1##

REFERENCES:
patent: 4576629 (1986-03-01), Morland et al.
patent: 5324841 (1994-06-01), Nishimura
March, J. Advanced Organic Chemistry. Reactions, Mechanisms and Structure: McGraw Hill. 1977. P. 367.
Liotta, C. L., Harris, H. P., McDermott, M., Gonzalez, T., and Smith, K. Chemistry of "Naked" Anions II. Reactions of the 18-Crown-6 Complex of Potassium Acetate with Organic Substrates in Aprotic Organic Solvents. Tetrahedron Letters 28, 2417, 1974.
Hamana, et al., UDC 547.821.07, vol. 81, "Studies on Tertiary Amine Oxide. IX. Reactions of 2-Substituted Pyridine 1-Oxides with Acetic Anhydride", pp. 574-578. (1961).
Chemical Abstracts, vol. 55, No. 24, 1961, Abstract No. 24743f.
Barnes, et al., Tetrahedron, vol. 38, No. 22, 1982, Oxford GB, pp. 3277-3280, "The Preparation of 4-and 6-Chloro-2 Chloromethylpyridine".

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