Method of preparing 11.beta., 17.alpha., 20, 21-tetrahydroxy ste

Details Method of preparing 11.beta., 17.alpha., 20, 21-tetrahydroxy ste Method of preparing 11.beta., 17.alpha., 20, 21-tetrahydroxy ste

1984-02-06

1986-05-13

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435911, C12P 3308, C12R 1645

Patent

active

045886830

ABSTRACT:
Disclosed herein is a method for preparing 11.beta., 17.alpha., 20, 21-tetrahydroxy steroids of the pregnane class. This method comprises incubating the corresponding 17.alpha., 20.alpha. or .beta., 21-trihydroxy steroid in the presence of a culture medium capable of effecting the 11.beta.-hydroxylation, such medium comprising a fungal culture of the genus Curvularia. Also disclosed herein is a method for preparing 11.beta., 17.alpha., 21-trihydroxy-20-oxo steroids of the pregnane class. This method comprises the hydroxylation method described hereinabove followed by conversion of the resulting 11.beta., 17.alpha., 20.alpha. or .beta., 21-tetrahydroxy steroid into the corresponding 11.beta., 17.alpha., 21-trihydroxy-20-oxo steroid.

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Cremonesi et al., Biotech. and Bioeng., 17, pp. 1101-1108 (1975).
Pfitzner et al., J.A.C.S., 87, pp. 5661-5678 (1965).

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