Method of preparation of optically active .alpha.-amino-acids

Details Method of preparation of optically active .alpha.-amino-acids Method of preparation of optically active .alpha.-amino-acids

1990-02-28

1991-06-25

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562507, 562560, C07C22700

Patent

active

050269062

ABSTRACT:
A new process of synthesis of optically active .alpha.-amino acids is described through nitrosation in a non-aqueous, aprotic system of the corresponding N-carbamyl derivatives followed by decomposition of the thus obtained N-nitroso derivatives in aqueous acidic medium. The process, which is of a general applicability, leads to a remarkable increase in the reaction yields, due to the suppression of the main side reaction leading to the corresponding .alpha.-hydroxy-acid. Some N-nitroso intermediates, which can be recovered from the process of the invention, are also described.

REFERENCES:
Lutsenko et al., Chem. Abst., vol. 94, #46,742h (1981).
Challis et al., Chem. Abst., vol. 91, #91276h (1974).
Ohashi et al., Chem. Abst., vol. 90, #39270w (1979).

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