Method of preparation of optically active alpha-amino-acids

Details Method of preparation of optically active alpha-amino-acids Method of preparation of optically active alpha-amino-acids

1988-04-14

1990-05-15

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562444, 562575, 562434, 562507, 562426, C07C 9900

Patent

active

049259784

ABSTRACT:
A new process of synthesis of optically active .alpha.-amino acids is described through nitrosation in a non-aqueous, aprotic system, of the corresponding N-carbamyl derivatives followed by decomposition of the thus obtained N-nitroso derivatives in aqueous acidic medium. The process, which is of a general applicability, leads to a remarkable increase in the reaction yields, due to the suppression of the main side reaction leading to the corresponding .alpha.-hydroxy-acid. Some N-nitroso intermediates, which can be recovered from the process of the invention, are also described.

REFERENCES:
Bonnett et al., J. Chem. Soc., Peck Tran 1, pp. 1969-1974 (1979).
Lulsenko, Chem. Abst., vol. 94, #46742n (1981).
Challis et al., Chem. Abst., vol. 91, #91276n (1979).

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