Method of preparation of controlled release nifedipine formulati

Details Method of preparation of controlled release nifedipine formulati Method of preparation of controlled release nifedipine formulati

1997-07-31

1999-05-11

Harrison, Robert H.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

427 221, A61K9/16

Patent

active

059026324

ABSTRACT:
A nifedipine formulation for oral administration is described that provides controlled, constant release of the pharmaceutical for about twenty four hours after a short delay following oral administration. There is also provided a method for preparing a controlled release formulation of nifedipine, which method includes coating pellets with multiple nifedipine-containing layers, along with an outer controlled release coating comprised of a water permeable polymer and lubricant/glidant. The pellets are then cured at an elevated temperature over several days. A method of using the formulations of the present invention for the treatment of patients is also described.

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