Method of preparation of .beta.-amino acids

Details Method of preparation of .beta.-amino acids Method of preparation of .beta.-amino acids

1998-02-13

2000-06-27

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544316, 546243, 546221, 548239, 548220, 548229, 548257, C07D41312, C07D23904, C07D211222, C07D26312, C07D24916

Patent

active

060808578

ABSTRACT:
A method for the preparation of .beta.-amino acid compounds is provided. The method includes contacting an amine nucleophile with an .alpha.,.beta.-unsaturated amide compound in the presence of a chiral Lewis acid complex. The chiral Lewis acid complex is formed from an azophilic metal salt and a chiral bisoxazolinylmethane compound. The selective amidolysis of one enantiomer of the .beta.-aminoamide product is also described.

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