Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-05-17
2005-05-17
McKane, Joseph K. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06894167
ABSTRACT:
A new method is described here for the synthesis of (S)-N-tert-butyl-1,2,3,4-tetrahydroiso-quinoline-3-carboxamide comprising the following steps:a) (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is reacted with formic acid to give the compound of formula:b) the compound thus obtained is reacted with tert-butylamine to give the compound of formula:c) the compound thus obtained is then treated with acids to give the desired compound.The method in question makes it possible to obtain (S)-N-tert-butyl-1,2,3,4-tetrahydroiso-quinoline-3-carboxamide with high yields and purity without using toxic and hazardous reagents.
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Bisulca Anthony A.
Clariant Life Science Molecules (Italia) S.p.A.
McKane Joseph K.
Robinson Binta
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