Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1997-02-27
2000-03-21
Weber, Jon P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514885, 514886, 514908, A61K 3578
Patent
active
06039949&
ABSTRACT:
The present invention is directed to a method of preparation and the composition of a water soluble extract of the plant species Uncaria. The present invention is also directed to the pharmaceutical use of the composition for the enhancement of the immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals. The present preparation of the water soluble extract of the plant species Uncaria results in the depletion of many of the ingredients which lead to various toxic side effects associated with other extracts or compositions derived from Uncaria. Also, the present preparation leads to the depletion of many of the active ingredients commonly associated with other extracts and compositions of the plant species Uncaria. Therefore, the present invention teaches that the hot water extraction of the crude plant parts of Uncaria and the subsequent dialysis of the solubilized products yields a low molecular weight composition which maintains a high degree of the anti-tumor, inflammatory and immune stimulatory activities associated with the crude plant parts.
REFERENCES:
patent: 4844901 (1989-07-01), Keplinger et al.
patent: 4940725 (1990-07-01), Keplinger et al.
patent: 5302611 (1994-04-01), Keplinger et al.
patent: 5411733 (1995-05-01), Hozumi et al.
Kuramochi et al., Life Sciences, 54:2061-2069, 1994.
Rizzi et al., Journal of Ethnopharmacology, 38:63-77, 1993.
Kiuchi et al., Chem. Pharm. Bull., 31:3391-3396, 1983.
New Polyhydroxylated Triterpenes From Uncaria Tomentosa, R. Aquino, F. De Simone, F.F. Vincieri, C. Pizza, Journal of Natural Products, vol. 53, No. 3, pp. 559-564, May-Jun. 1990.
Plant Metabolites Structure And In Vitro Antiviral Activity Of Quinovic Acid Glycosides From Uncaria Tomentosa And Guettarda Playtypoda, R. Aquino, F. De Simone, C Pizza, Journal of Natural Products, vol. 52, No. 4, pp. 679-685, Jul.-Aug. 1989.
Plant Metabolites New Compounds And Antiflammatory Activity of Uncaria Tomentosa, Rita Aquino, Vicenzo De Feo, Francesco De Simone, Cosimo Pizza, and Giuseppe Cirino, Journal of Natural Products, vol. 54, No. 2, pp. 453-459, Mar.-Apr. 1991.
Francesco De Simone, Cosimo Pizza, and Giuseppe Cirino, Journal of Natural Products, vol. 54, No. 2, pp. 453-459, Mar.-Apr. 1991.
Plant-Derived Natural Products in Drug Discovery and Development, Manuel F. Balandrin, A. Douglas Kinghorn and Norman R. Farnsworth, 1993 American Chemical Society (Chapter 1).
Phytomedicines in Western Europe--Potential Impact on Herbal Medicine in the United States, Varro E. Tyler Dept. of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333, 1993 American Chemical Society (Chapter 3).
Role of Plants in the National Cancer Institute Drug Discovery and Development Program, Gordon M. Cragg, Michael R. Boyde, John H. Cardellina II, and Matthew Suffnmess, Published 1993 American Chemical Society (Chapter 7).
Una de Gato (Cat's Claw) Rainforest herb gets scientific and industry attention, by Mark Blumenthal, Whole Foods Magazine, Oct. 1995, pp. 62,64,66,68 & 78.
Apoptosis and a re-investigation of the biologic basis for cancer therapy, Anthony V. D'Amico, W. Gillies McKenna Radiotherapy and Oncology 33 (1994) 3-10.
Apoptosis in the Pathogenesis and Treatment of Disease, Craig B. Thompson, Science, vol. 267, Mar. 10, 1995.
CampaMed, Inc.
Kerr Janet M.
Weber Jon P.
LandOfFree
Method of preparation and composition of a water soluble extract does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of preparation and composition of a water soluble extract, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparation and composition of a water soluble extract will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-728086