Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2004-06-16
2010-02-02
Kapushoc, Stephen (Department: 1634)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120, C536S024300, C536S024330, C536S023100, C536S024100
Reexamination Certificate
active
07655444
ABSTRACT:
The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain types of chemotherapeutic agents. Alkylating agents, used for the treatment of certain types of tumors including tumors of the nervous system and lymph system, are efficacious agents when the damage they do to tumor cell DNA is not repaired by cellular DNA repair mechanisms. The present invention provides a method for determining the activity of a gene encoding a DNA repair enzyme, thus providing a prediction of the clinical response to alkylating agents.
REFERENCES:
patent: 5407804 (1995-04-01), Yarosh
patent: 5817514 (1998-10-01), Li et al.
patent: 6773897 (2004-08-01), Herman et al.
patent: WO 93/24837 (1993-12-01), None
patent: WO 00/05419 (2000-02-01), None
patent: WO 00/51369 (2000-08-01), None
patent: WO 02/068694 (2002-09-01), None
Herman et al, Proc. Natl. Acad. Sci. USA, vol. 93, pp. 9821-9826, Sep. 1996.
Woodcock et al, J. Biological Chemistry, vol. 272, No. 12, pp. 7810-7816, Mar. 21, 1997.
Lenz G et al ‘Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia.’ Ann Hematol. Oct. 2004;83(10):628-33.
Costello JF et al ‘Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.’ Nat Genet. Feb. 2000;24(2):132-8.
Costello JF et al ‘Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.’ J Biol Chem. Jun. 24, 1994;269(25):17228-37.
Rietschel P. et al ‘Phase II Study of Extended-Dose Temozolomide in Patients With Melanoma’ J Clinical Oncology )2008) vol. 26, No. 14, pp. 2299-2304.
Sekiguchi M. et al, J Cancer Res Clin Oncol (1996) 122:199-206.
Brabender J. et al, Clinical Cancer Research (2003) vol. 9, p. 223-227.
Juppner H, Bone (1995) vol. 17, No. 2, Supplement, pp. 39S-42S.
Bearzatto et al., “Epigenetic Regulation of theMGMTandhMSH6DNA Repair Genes in Cells Resistant to Methylating Agents”,Cancer Research, 60:3262-3270 (2000).
Esteller et al., “Inactivation of the DNA Repair Gene06-Methylguanine-DNA Methyltransferaseby Promoter Hypermethylation is a Common Event in Primary Human Neoplasia”,Cancer Research, 59:793-797 (1999).
Esteller et al., “Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents”,The New England Journal of Medicine, 343(19):1350-1654 (2000).
Esteller et al., “Promoter Hypermethylation of the DNA Repair Gene MGMT Predicts Survival and Response to Regimens Containing the Alkylating Agent Cyclophosphamide in B-Cell Diffuse Large Cell Lymphoma”,Proceedings of the American Association for Cancer Research, 42:347 (2001).
Herfarth et al., “A Specific CpG Methylation Pattern of theMGMTPromoter Region Associated with Reduced MGMT Expression in Primary Colorectal Cancers”,Molecular Carcinogenesis, 24:90-98 (1999).
Mineura et al., “Human Brain Tumor06-Methylguanine-DNA Methyltransferase mRNA and Its Significance as an Indicator of Selective Chloroethylnitrosourea Chemotherapy”,Int. J. Cancer(Pred. Oncol.), 69:420-425 (1996).
Baylin Stephen B.
Esteller Manel
Herman James G.
DLA Piper (LLP) US
Kapushoc Stephen
The Johns Hopkins University School of Medicine
LandOfFree
Method of predicting the clinical response to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of predicting the clinical response to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of predicting the clinical response to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4196147