Method of photodynamic therapy employing electron trapping mater

Details Method of photodynamic therapy employing electron trapping mater Method of photodynamic therapy employing electron trapping mater

1989-02-21

1990-12-25

Rosenbaum, C. Fred

Surgery

Radioactive substance applied to body for therapy

Combined with other radiant or wave energy source

540145, 424 11, A61N 502, C07B 4700, A61K 4300

Patent

active

049799355

ABSTRACT:
A method of photodynamic therapy employing an electron trapping material as the light source. The electron trapping material is charged with light, which raises electrons in the material from a ground level to a higher trapping energy level. The material is then introduced into a patient's body, where it delivers light to and activates an antibody which has been retained in cancerous tissue. The electron trapping material can be either a deep trap or shallow trap phosphor. In the former case, stimulation of the charged material with infrared energy releases electrons from their traps, resulting in the emission of light within the patient's body. In the latter case, the material emits light immediately after charging with an intensity that decreases in inverse porportion to time. The electron trapping material may be provided in the form of a powder which can be inhaled for treatment of lung cancer, or suspended in a liquid which can be ingested, injected, or circulated in cavities of the body to treat other organs.

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Mew et al., "Photoimmunotherapy: Treatment of Animal Tumors with Tumor Specific Monoclonal Antibody-Hematoporphyrin Conjugates", Journal of Immunology, vol. 130, No. 3, Mar. 1983, pp. 1473-1477.
Weishaupt et al., "Identification of Singlet Oxgyen as the Cytotoxic Agent in Photo-Inactivation of a Murine Tumor", Cancer Research, vol. 36, pp. 2326-2329, Jul. 1976.

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