Method of photo-oxidative treatment of tissues containing collag

Bleaching and dyeing; fluid treatment and chemical modification – Treatment of hides – skins – feathers and animal tissues – Internal tissues

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8 9418, 8404, 20415768, 623 13, 623 16, 623 11, A61L 1700

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058171533

ABSTRACT:
In the method of a photo-oxidative treatment of tissue containing collagen tissue, the tissue is pre-treated with an aqueous conditioning solution prior to an irradiation with light. In this pre-treatment the tissue permeable to the solution is loaded with a dye contained in the solution, in particular with methylene blue. This dye, activated by light, catalyzes photo-oxidative reactions. In accordance with the invention a substance is added to the conditioning solution, the refractive index of which is greater than that of water. As a result of this additive, the tissue containing collagen assumes a greater transparency for light during the pre-treatment.

REFERENCES:
patent: 3152976 (1964-10-01), Kuntz
patent: 5147514 (1992-09-01), Mechanic
patent: 5409479 (1995-04-01), Dew et al.
Ramshaw, John A.M., et al. (1994) "Methylene blue sensitized photooxidation of collagen fibrils", Biochimica et Biophysica Acta, 1206(2):225-230 (Month Unknown).
Moore, M.A., et al. (1994) "Stabilization of pericardial tissue by dye-mediated photooxidation", Journal of Biomedical Materials Research, 28(5):611-618 (Month Unknown).

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