Method of performing multiple synthesis of peptides on solid car

Details Method of performing multiple synthesis of peptides on solid car Method of performing multiple synthesis of peptides on solid car

1991-01-24

1993-04-13

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 422 64, 422 72, 422116, A61K 3702, G01N 2100

Patent

active

052024180

ABSTRACT:
The invention relates to a method and apparatus for performing a multiple synthesis of peptides on a solid carrier. Active components are successively bonded to functional groups anchored on a carrier. The carrier planar functionalized porous material divided into compartments, into which the needed activated component is put. Common operations of the synthesis are carried out by all compartments of the carrier at the same time.

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Eichler, "Application of Cellulose Paper as Support Material in Simultaneous Solid Phase Synthesis," Collect. Czech. Chem. Commun., vol. 54, pp. 1746-1752 (1989).
Merrifield, Angewandte Chemie vol. 24 No. 10 (Oct. 1985) at 799-810.
Houghten, PNAS USA vol. 82 5131-5135 (Aug. 1985).
Frank et al., Tetrahedron vol. 44 No. 19 6031-40 (1988).

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