Method of performing gradient-based assays in a microfluidic...

Details Method of performing gradient-based assays in a microfluidic... Method of performing gradient-based assays in a microfluidic...

2006-09-26

2006-09-26

Le, Ong V. (Department: 1641)

Chemistry: analytical and immunological testing

Automated chemical analysis

With a continuously flowing sample or carrier stream

C436S053000, C436S172000, C436S177000, C436S180000, C422S081000, C422S082000, C422S082080, C422S105000

Reexamination Certificate

active

07112444

ABSTRACT:
A method is provided for performing a gradient-based assay in a microfluidic device. The method includes the steps of passing first and second fluids through a channel in the microfluidic device. The first fluid has a predetermined concentration of particles therein such that the particles in the first fluid diffuse into the second fluid so as to cause a gradient of concentration of particles in the second fluid as the second fluid flows through the channel. The second fluid sequentially intersects a series of targets along the channel wall as the second fluid flows through the channel.

REFERENCES:
patent: 3692486 (1972-09-01), Glenn
patent: 4012198 (1977-03-01), Finter et al.
patent: 5716852 (1998-02-01), Yager et al.
patent: 5770388 (1998-06-01), Vorpahl
patent: 5869004 (1999-02-01), Parce et al.
patent: 5932100 (1999-08-01), Yager et al.
patent: 5942443 (1999-08-01), Parce et al.
patent: 5948684 (1999-09-01), Weigl et al.
patent: 5972710 (1999-10-01), Weigl et al.
patent: 6004515 (1999-12-01), Parce et al.
patent: 6046056 (2000-04-01), Parce et al.
patent: 6090545 (2000-07-01), Wohlstadter et al.
patent: 6103479 (2000-08-01), Taylor
patent: 6103536 (2000-08-01), Geisberg
patent: 6134950 (2000-10-01), Forster et al.
patent: 6140134 (2000-10-01), Rittenburg
patent: 6150180 (2000-11-01), Parce et al.
patent: 6159686 (2000-12-01), Kardos et al.
patent: 6171865 (2001-01-01), Weigl et al.
patent: 6176962 (2001-01-01), Soane et al.
patent: 6200814 (2001-03-01), Malmqvist et al.
patent: 6221677 (2001-04-01), Wu et al.
patent: 6277641 (2001-08-01), Yager
patent: 6297061 (2001-10-01), Wu et al.
patent: 6306590 (2001-10-01), Mehta et al.
patent: 6316267 (2001-11-01), Bhalgat et al.
patent: 6322683 (2001-11-01), Wolk et al.
patent: 6475441 (2002-11-01), Parce et al.
patent: 6596545 (2003-07-01), Wagner et al.
patent: 6613581 (2003-09-01), Wada et al.
patent: 6649358 (2003-11-01), Parce et al.
Dertinger et al., “Generation of Gradients Having Complex Shapes Using Microfluidic Networks,”Analytical Chemistry, vol. 73, No. 6, Mar. 15, 2001, pp. 1240-1246.
Jeon et al., “Generation of Solution and Surface Gradients Using Microfluidic Systems,”Langmuir2000, 16, 8311-8316.
Beebe et al., “Microfluidic tectonics: A comprehensive construction platform for microfluidic systems,”PNAS, 13488-13493, Dec. 5, 2000, vol. 97, No. 25.

Affiliated with

Also associated with

Rating

Method of performing gradient-based assays in a microfluidic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of performing gradient-based assays in a microfluidic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of performing gradient-based assays in a microfluidic... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3584457