Method of peptide synthesis

Details Method of peptide synthesis Method of peptide synthesis

1988-01-28

1990-10-23

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530336, 530327, 530328, C07K 102, C07K 104, C07K 706

Patent

active

049653431

ABSTRACT:
A method for the solid phase synthesis of multi-sulfated peptides comprising coupling side-chain unprotected hydroxyamino acids to the peptide chain utilizing benzotriazol-1-yl-oxy-tris (dimethyl)-phosphonium hexafluorophosphate (BOP) as a coupling reagent.

REFERENCES:
patent: 4769445 (1988-09-01), Constoch et al.
Fourrier, A. et al., Int. J. Peptide Protein Res., 33: 133-139, 1989.
The Proteins, vol. II, 3rd ed., Ed.; Neurath, Hill, Boeder, Academic Press, 1976.
Fournier, A., et al., Int. J. Peptide Protein Res. 31: 86-97, 1988.
Felix, A., et al., Int. J. Peptide Protein Res. 31: 231-238, 1988.
Le Nguyen, D., et al., Peptide Chemistry, 1987, 231-238, T. Shiba & S.Sakakibara (Editors), pub. 1988.
Penke, B., et al., J. Org. Chem., 52: 1197-1200, 1987.
Penke, B., et al., J. Med. Chem., 27: 845-894, 1984.
Le Nguyen, D., J. Chem. Soc. Penkin Trans. I: 1915-1919, 1987.
Casto, B., et al., Tett. Lett., 14: 1219-1222, 1975.
Pluslec, T., J. Med. Chem., 13; 349-352, 1970.
Toth, G., et al., Int. J. Peptide Protein Res., 26: 630-638, 1985.
Castro, et al., Pept., Proc. Eur. Pept. Symp., 13th, 1974, Nolman, Yechesnel (Ed.), pub. 1975.
Ondetti, M., JACS, 92: 195-199, 1970.
Castro, Journal of the Chemical Society, Perkin Translation, I., 1025 (1985).
Rivaile, Tetrahedron, 36, 3143 (1980).
Audousset-Puech et al., FEBS Letters, 200: 181 (1986).

Affiliated with

Also associated with

Rating

Method of peptide synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of peptide synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of peptide synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-767671