Method of oriented depositing chemically defined bodies

Details Method of oriented depositing chemically defined bodies Method of oriented depositing chemically defined bodies

1998-04-29

2000-08-01

Pianalto, Bernard

Coating processes

Direct application of electrical, magnetic, wave, or...

Polymerization of coating utilizing direct application of...

427261, 4274071, 427511, 427558, 427559, 427595, C08J 704

Patent

active

060963867

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

The invention is related to a method of depositing chemically defined bodies on a substrate surface. The bodies have at least partially a predetermined chemical composition and may comprise molecules, macromolecules or also nanostructures composed of molecules or macromolecules.


BACKGROUND OF THE INVENTION

In the article "Scenes From a Marriage--Of Optics and Electronics" by Robert F. Service in Science, Vol. 268, Jun. 23, 1995, a method is described which is called fluidic self-assembly. Therein small optical components, such as lasers are mixed with a fluid, such as ethanol and are poured over a silicon wafer which comprises holes matching the shape of the lasers. Bit by bit the lasers settle into the holes under the influence of gravity. When a laser goes in a hole properly it stays there because it is effectively removed from the shear forces associated with the movement of the liquid that otherwise would carry the lasers away. By this method no alignment is needed to help the lasers go where they shall be located. However, no additional specific force guides the lasers to their destination.
The article "Direct Measurement of the Forces Between Complementary Strands of DNA" by Lee, Chrisey and Colton in Science, Vol. 266, Nov. 4, 1994, is related to interaction forces between single strands of DNA. Therefor, two surfaces covered with DNA strands are brought in near vicinity until the attractive forces of the strands effect a chemical binding such that the surfaces are held together by a specific force.
In "Immobilization of Antibodies on a Photoactive Self-Assembled Monolayer on Gold" by Delamarche et al. in Langmuir, Vol. 12, Nr. 8, pp. 1997-2006, Jan. 4, 1996 a strategy for immobilizing biomolecules on a photoactivable surface is discussed. Therefor, a gold substrate is functionalized with a dialkyl disulfide which forms a self-assembled monolayer (SAM). Afterwards the reactive ester groups at the termini of the SAM are converted into photoactivable groups based on benzophenone. This photoactivable group acts as a crosslinking agent that is inert under ambient light and is activated by near-UV light. UV irradiation causes biradical formation at the ketyl center of the benzophenone. Thereby, a molecule or macromolecule such as a protein undergoes covalent attachment to the substrate via the SAM. Proteins deposited on a solid substrate find applications e.g. in enzyme-based biosensors and in forming biocompatible surfaces.
Microcontact printing is the subject of the article "Patterning Self-Assembled Monolayers: Applications in Materials Science" by Kumar, Biebuyck and Whitesides in Langmuir, Vol. 10, Nr. Feb. 5, 1994, pp. 1498-1511. Polydimethylsiloxane (PDMS) is used as material of a stamp which is patterned by using a lithographic process. The stamp is then provided with alkanethiol serving as "ink" for the following stamping process. By touching a gold substrate surface the protrusions of the pattern transfer thiol onto the substrate where it forms a patterned SAM. The molecules in these SAMs are arranged in ordered crystalline domains on the surface of the substrate having one of their ends attached covalently to this surface and the other end extending upright, away from the substrate. Thus, the new surface of a substrate printed upon with thiol has interfacial properties characteristic of one end of the molecules of the SAM. This SAM can be used in a following step as a mask for an etching step such that the pattern is transferred into the surface of the substrate. The alkanethiol molecules are not oriented on the stamp with this procedure.
Further known is a method called the Langmuir-Blodgett process. Information about this process may be derived from A. Ulman's "An Introduction to Ultrathin Films", Academic Press, San Diego, Calif., 1991. This method of thin-film formation organizes molecules at an air-water interface (Langmuir film). Organization results from progressively greater lateral confinement of the molecules at the air-water interface by use of a moveable mechani

REFERENCES:
patent: 5512131 (1996-04-01), Kumar et al.
Kim et al. "Combining Patterned Self-Assembled Monolayers of Alkanethiolates on Gold With Anisotropic etching of Silicon to Generate Controlled Surface Morphologies", J. Electrochem Soc. vol. 142, No. 2, Feb. 1995, pp. 628-633.
"Scenes From a Marriage-of Optics and Electronics", Science, vol. 268, Jun. 23, 1995, pp. 1702-1703.

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