Method of oligonucleotide synthesis

Details Method of oligonucleotide synthesis Method of oligonucleotide synthesis

2008-01-01

2008-01-01

Kim, Young J. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C536S023100, C536S025300

Reexamination Certificate

active

10741068

ABSTRACT:
Methods and kits for synthesizing a plurality of oligonucleotides are provided. Methods for providing a plurality of oligonucleotides enriched for full length oligonucleotides are provided. Truncated oligonucleotides are preferentially removed from the sample by digestion. Methods are also provided for amplification of a plurality of oligonucleotides.

REFERENCES:
patent: 5242794 (1993-09-01), Whiteley et al.
patent: 5455166 (1995-10-01), Walker
patent: 5470723 (1995-11-01), Walker et al.
patent: 5523204 (1996-06-01), Singer et al.
patent: 5561044 (1996-10-01), Walker et al.
patent: 5631147 (1997-05-01), Lohman et al.
patent: 5648211 (1997-07-01), Fraiser et al.
patent: 5712124 (1998-01-01), Walker
patent: 5736365 (1998-04-01), Walker et al.
patent: 5744311 (1998-04-01), Fraiser et al.
patent: 5856092 (1999-01-01), Dale et al.
patent: 5874260 (1999-02-01), Cleuziat et al.
patent: 5916779 (1999-06-01), Pearson et al.
patent: 5935793 (1999-08-01), Wong
patent: 5952174 (1999-09-01), Nikiforov et al.
patent: 6017738 (2000-01-01), Morris et al.
patent: 6087133 (2000-07-01), Dattagupta et al.
patent: 6191267 (2001-02-01), Kong et al.
patent: 6214587 (2001-04-01), Dattagupta et al.
patent: 6238868 (2001-05-01), Carrino et al.
patent: 6531302 (2003-03-01), Nerenberg et al.
patent: 6638719 (2003-10-01), Gunderson et al.
patent: 6709816 (2004-03-01), Huang et al.
patent: 6864071 (2005-03-01), Carrino et al.
patent: 6867028 (2005-03-01), Janulaitis et al.
patent: 6867294 (2005-03-01), Sanghvi et al.
patent: 6884586 (2005-04-01), Van Ness et al.
patent: 2003/0104430 (2003-06-01), Nerenberg et al.
patent: 2003/0211506 (2003-11-01), Kong et al.
patent: 2003/0232348 (2003-12-01), Jones et al.
patent: 2004/0115644 (2004-06-01), Dong
patent: 500224 (1992-08-01), None
patent: 676476 (1995-10-01), None
patent: 819768 (1998-01-01), None
patent: 713922 (1999-09-01), None
patent: WO 0053617 (2000-09-01), None
deBaer et al. A universal glass support for oligonucleotide synthesis. Nucleosides & Nucleotides 6(5), pp. 821-830 (1987).
Zhu et al. Engineering strand-specific DNA nicking enzymes from the type IIS restriction endonucleases Bsal, BsmBl, and BsmAl. J Mol Biol. Mar. 26, 2004; 337(3):573-83.
Applied Biosystems, DNA/RNA Synthesizers Models 392 and 394 User's Manual. 16 pages total, Jun. 2001.
Caruthers et al. Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method. Methods Enzymol. 1987;154:287-313.
Spargo et al. Detection of M. tuberculosis DNA using thermophilic strand displacement amplification. Mol Cell Probes. Aug. 1996;10(4):247-56.
Nikiforov et al. “The use of phosphorothioate primers and exonuclease hydrolysis for the preparation of single-stranded PCR products and their detection by solid-phase hybridization.” PCR Methods Appl. Apr. 1994;3(5):285-91.
Syvanen, “Accessing genetic variation: genotyping single nucleotide polymorphisms.” Nat Rev Genet. Dec. 2001;2(12):930-42.
Engler and Richardson. “Bacteriophage T7 DNA replication. Synthesis of lagging strands in a reconstituted system using purified proteins.” J Biol Chem. Sep. 25, 1983;258(18):11197-205.
Ravikumar et al. “Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis.” Bioorg Med Chem. Oct. 15, 2003;11(21):4673-9.
Claeboe et al. “3′-modified oligonucleotides by reverse DNA synthesis.” Nucleic Acids Res. Oct. 1, 2003;31(19):5685-91. Nucleic Acids Res. Oct. 1, 2003;31(19):5685-91.

Affiliated with

Also associated with

Rating

Method of oligonucleotide synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of oligonucleotide synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of oligonucleotide synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3941698