Method of oligonucleotide synthesis

Details Method of oligonucleotide synthesis Method of oligonucleotide synthesis

2008-01-01

2008-01-01

Kim, Young J. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C536S023100, C536S025300

Reexamination Certificate

active

07314714

ABSTRACT:
Methods and kits for synthesizing a plurality of oligonucleotides are provided. Methods for providing a plurality of oligonucleotides enriched for full length oligonucleotides are provided. Truncated oligonucleotides are preferentially removed from the sample by digestion. Methods are also provided for amplification of a plurality of oligonucleotides.

REFERENCES:
patent: 5242794 (1993-09-01), Whiteley et al.
patent: 5455166 (1995-10-01), Walker
patent: 5470723 (1995-11-01), Walker et al.
patent: 5523204 (1996-06-01), Singer et al.
patent: 5561044 (1996-10-01), Walker et al.
patent: 5631147 (1997-05-01), Lohman et al.
patent: 5648211 (1997-07-01), Fraiser et al.
patent: 5712124 (1998-01-01), Walker
patent: 5736365 (1998-04-01), Walker et al.
patent: 5744311 (1998-04-01), Fraiser et al.
patent: 5856092 (1999-01-01), Dale et al.
patent: 5874260 (1999-02-01), Cleuziat et al.
patent: 5916779 (1999-06-01), Pearson et al.
patent: 5935793 (1999-08-01), Wong
patent: 5952174 (1999-09-01), Nikiforov et al.
patent: 6017738 (2000-01-01), Morris et al.
patent: 6087133 (2000-07-01), Dattagupta et al.
patent: 6191267 (2001-02-01), Kong et al.
patent: 6214587 (2001-04-01), Dattagupta et al.
patent: 6238868 (2001-05-01), Carrino et al.
patent: 6531302 (2003-03-01), Nerenberg et al.
patent: 6638719 (2003-10-01), Gunderson et al.
patent: 6709816 (2004-03-01), Huang et al.
patent: 6864071 (2005-03-01), Carrino et al.
patent: 6867028 (2005-03-01), Janulaitis et al.
patent: 6867294 (2005-03-01), Sanghvi et al.
patent: 6884586 (2005-04-01), Van Ness et al.
patent: 2003/0104430 (2003-06-01), Nerenberg et al.
patent: 2003/0211506 (2003-11-01), Kong et al.
patent: 2003/0232348 (2003-12-01), Jones et al.
patent: 2004/0115644 (2004-06-01), Dong
patent: 500224 (1992-08-01), None
patent: 676476 (1995-10-01), None
patent: 819768 (1998-01-01), None
patent: 713922 (1999-09-01), None
patent: WO 0053617 (2000-09-01), None
deBaer et al. A universal glass support for oligonucleotide synthesis. Nucleosides & Nucleotides 6(5), pp. 821-830 (1987).
Zhu et al. Engineering strand-specific DNA nicking enzymes from the type IIS restriction endonucleases Bsal, BsmBl, and BsmAl. J Mol Biol. Mar. 26, 2004; 337(3):573-83.
Applied Biosystems, DNA/RNA Synthesizers Models 392 and 394 User's Manual. 16 pages total, Jun. 2001.
Caruthers et al. Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method. Methods Enzymol. 1987;154:287-313.
Spargo et al. Detection of M. tuberculosis DNA using thermophilic strand displacement amplification. Mol Cell Probes. Aug. 1996;10(4):247-56.
Nikiforov et al. “The use of phosphorothioate primers and exonuclease hydrolysis for the preparation of single-stranded PCR products and their detection by solid-phase hybridization.” PCR Methods Appl. Apr. 1994;3(5):285-91.
Syvanen, “Accessing genetic variation: genotyping single nucleotide polymorphisms.” Nat Rev Genet. Dec. 2001;2(12):930-42.
Engler and Richardson. “Bacteriophage T7 DNA replication. Synthesis of lagging strands in a reconstituted system using purified proteins.” J Biol Chem. Sep. 25, 1983;258(18):11197-205.
Ravikumar et al. “Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis.” Bioorg Med Chem. Oct. 15, 2003;11(21):4673-9.
Claeboe et al. “3′-modified oligonucleotides by reverse DNA synthesis.” Nucleic Acids Res. Oct. 1, 2003;31(19):5685-91. Nucleic Acids Res. Oct. 1, 2003;31(19):5685-91.

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