Method of off-resonance detection using complementary MR...

Details Method of off-resonance detection using complementary MR... Method of off-resonance detection using complementary MR...

2005-11-10

2010-10-05

Casler, Brian (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C424S009300

Reexamination Certificate

active

07809424

ABSTRACT:
Off-resonance imaging uses two complementary contrast agents with the first agent (iron-oxide) particles transfected into cells which provide localized signals. The second agent is detected from a change in the off-resonance signal when present in the cells labeled by the first agent.

REFERENCES:
patent: 7502640 (2009-03-01), Conolly et al.
patent: 2005/0261575 (2005-11-01), Conolly
Cunningham et al. Positive Contrast Magnetic Resonance Imaging of Cells Labeled with Magnetic Nanoparticles. Magnetic Resonance in Medicine. 53:999-1005. 2005.
Weissleder R et al. Magnetically labeled cells can be detected by MR imaging. Journal of Magnetic Resonance Imaging. 7:258-263. 1997.
Schenck JF et al. The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds. Med Phys. 23:815-843. 1996.
Frank JA et al. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology. 228:480-487. 2003.

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