Method of obtaining urokinase

Details Method of obtaining urokinase Method of obtaining urokinase

1976-07-01

1977-06-07

Shapiro, Lionel M.

Textiles: fiber preparation

C07G 7026

Patent

active

040281876

ABSTRACT:
A method of obtaining urokinase directly from human urine comprising contacting human urine with an acrylonitrile polymer of a unique porous structure formed at the time of polymerization for formation of the polymer and having a porosity of not less than 10% and a specific surface area of 5 m.sup.2 /g. and subsequently eluting the urokinase adsorbed on the polymer. The acrylonitrile polymer employed in the method of the present invention has an excellent adsorption activity to urokinase and therefore, with use of an extremely small amount of the adsorbent, the satisfactory results can be obtained. Moreover, the porous polymer of the present method can also be utilized for purification of low purity crude urokinase obtained by the prior art methods.

REFERENCES:
patent: 3723251 (1973-03-01), Ogawa et al.
patent: 3957582 (1976-05-01), Stried et al.

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