Method of obtaining urethane-protected N-carboxyanhydrides...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07667051

ABSTRACT:
The invention relates to a method of preparing urethane-protected N-carboxyanhydrides of alpha amino acids. The inventive method enables the synthesis of urethane-protected N-carboxyanhydrides of alpha amino acids in the presence of a catalytic quantity of triethylene diamine without the addition of a tertiary amine-type base.

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Shin et al. (AN 1989:76079, HCAPLUS, abstract: JP 63112565).
Fuller et al., “Urethane-Protected ∝-Amino Acid N-Carboxyanhydrides and Peptide Synthesis” Biopolymers (Peptide Science), vol. 40, pp. 183-205, John Wiley & Sons, Inc. 1996.
Okumura et al., “Dehydrooligopeptides. XIV. Syntheses of 2-[(Z)-1-Amino-1-alken-1-yl]oxazole-4-carboxylic Acid and the Main Common Skeleton of Thiostrepton Peptide Antibiotics, A10255G and J”, Bulletin of the Chemical Society of Japan, vol. 69, No. 8, 1996.

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