Method of obtaining immunogenic peptides from cells expressing t

Details Method of obtaining immunogenic peptides from cells expressing t Method of obtaining immunogenic peptides from cells expressing t

1993-05-21

1996-01-30

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 703, 435 704, 530300, 530333, C07K 100, C07K 200, C12P 2100

Patent

active

054879825

ABSTRACT:
Genetically engineered temperature-sensitive class I HLA mutants are provided which can be used in a method to obtain peptides which are bound to MHC class I molecules on the surfaces of cells that are transfected with the mutant genes.

REFERENCES:
Rock et al., J. Immunol. 150:1244-1252 (1993).
Salter, J. Cell Biochem., Suppl. 16 Part D, p. 22 (1992).
Pamer, et al., Nature 353:852-854 (1991).

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