Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-04
2010-11-30
Solola, Taofiq A (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07842821
ABSTRACT:
The invention is aimed at a compound of formula (I) wherein n is 0, 1 or 2, R1is a linear or branched alkyl group, R2is selected from a substituted or non substituted alkyl group, substituted or non substituted aryl group, substituted or non substituted aralkyl group, substituted or non substituted heterocyclyl group, or a substituted or non substituted heterocyclylalkyl group. Another object of the invention is a process for obtaining these compounds from the corresponding compound with a hydroxy group in position 4 by means of reacting with a sulfonamide in the presence of a phosphine and a dialkyl azadicarboxylate. The deprotection of the compound of formula (I) gives rise to the corresponding amine. The intermediate and the processes described are very useful in the synthesis of pharmaceutical products.
REFERENCES:
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patent: 1 329 453 (2003-07-01), None
Edwards, Michael L., et al., “Stereospecific synthesis of secondary amines by the Mitsunobu reaction”, “Tetrahedron Lett.”, pp. 3417-3420, vol. 31, No. 24.
Fukuyama, Tohru, et al., “2- and 4-Nitrobenzenesulfonamides: Exceptionally versatile means for preparation of secondary amines and protection . . . ”, “Tetrahedrom Lett.”, Sep. 4, 1995, pp. 6373-6374, vol. 36, No. 36.
Fukuyama, Tohru, et al., “2,4-Dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines . . . ”, “Tetrahedron Lett.”, Aug. 18, 1997, pp. 5831-5834, vol. 38, No. 33.
Thomas, S.M., et al., “In-process test for synthesis of Dorzolamide Hydrochloride”, “At-Process”, 1997, pp. 432-439, vol. 2, No. 5-6.
Guisasola Luis Octavio Silva
Juárez Jorge Martín
Lobato José María Gorgojo
Hultquist Steven J.
Intellectual Property / Technology Law
Ragactives, S.L.
Solola Taofiq A
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