Method of obtaining D-glucuronic acid

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S124000

Reexamination Certificate

active

10956474

ABSTRACT:
A method of obtaining D-glucuronic acid. The D-glucuronic acid and its derivatives (lactone, salts, amides, etc.) are biologically high-active compounds, which are widely used in medicine and pharmaceutical chemistry for the synthesis of modified drugs as well as used as food additives, skin-care preparations, and the like. This invention provides an environmentally friendly method of obtaining D-glucuronic acid which has widespread operational possibilities. The D-glucuronic acid is obtained by heating the salts of 1,2-0-isopropylidene-D-glucuronic acid in a water-containing solution in the presence of an acid agent, for which sulphonic acid cation exchanger resins are used.

REFERENCES:
patent: 670928 (1952-04-01), None
Rist, C. E. et a,l J. Am. Chem. Soc. 1951, 73, 2424-27.
Hawley's Condensed Chemical Dictionary, 1997, p. 426.
Israelstam et al J.Org. Chem. 1961, 26, 240-242.
C.L. Mehltretter et al., “A Practical Synthesis of D-Glucuronic Acid through the Catalytic Oxidation of 1,2-Isopropylidene-D-glucose”, J. Am. Chem. Soc., 1951, V. 73, No. 6, pp. 2424-2427.

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