Method of obtaining collagen human-skin fibers, fibers thus prod

Details Method of obtaining collagen human-skin fibers, fibers thus prod Method of obtaining collagen human-skin fibers, fibers thus prod

1990-06-28

1992-05-26

Willis, Jr., Prince

Bleaching and dyeing; fluid treatment and chemical modification

Chemical modification of textiles or fibers or products thereof

Proteinaceous fibers

8 9411, 128DIG8, 530356, D06M 1300

Patent

active

051163896

ABSTRACT:
Human-skin collagen fibers are obtained from sterile pieces of human skin by first comminuting the sterile skin and then mixing the comminuted sterile skin with a sterile aqueous solution of an alkaline-metal or alkaline-earth salt to form a suspension. This suspension is then diluted with a promoter of fibrillogenesis taken from the group formed by acetylated glucosamine, n-acetyl neuraminic acid, and mixtures thereof and the pH of the suspension is set to a value between 4 and 6. The diluted suspension is then left to ripen while fibers grow in it. Collagen fibers are then separated from the suspension and are checked under a microscope for the presence of protein impurities. If any such fraction is then found the fibers are rinsed by agitation with an atoxic aqueous solution of a nonionic detergent, then the residual protein impurities are separated out to obtain an aqueous suspension of collagen fibers having no foreign matter, and finally the collagen fibers are rinsed in steriized water. The fibers thus obtained are implanted back into the patient from whom the skin was originally recovered.

REFERENCES:
patent: 3949073 (1976-04-01), Daniels et al.

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