Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1982-01-25
1984-10-23
Phillips, Delbert R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260112R, 424 85, 424 88, 424177, C07C10352, C07G 700, A61K 3900, A61K 3700
Patent
active
044787448
ABSTRACT:
Antibodies specific to glycosylated hemoglobin and substantially free of cross-reactivity with nonglycosylated forms of hemoglobin are obtained by administering a synthetic antigen to a host animal. The antigen comprises a glycosylated synthetic peptide having an amino acid sequence corresponding to that of the NH.sub.2 -terminus of the .beta.-chain of hemoglobin. The peptide comprises a sequence of between about four and ten, and preferably seven, amino acids, and is conjugated with glucose and a protein. The protein preferably comprises an immunoglobulin which is foreign to the host animal.
REFERENCES:
Chou, et al., "Development of a Laser Nephelometric Method for the Quantitation of Human Glycohemoblogins", Analytical Letters, vol. 14 (B13) at 1071-1087, (1981).
Merrifield, R. B., "Solid Phase Peptide Synthesis, I, The Synthesis of a Tetrapeptide", JACS, vol. 85, p. 2149, (1963).
Javid, et al., British Journal of Haematology, vol. 38 at 329-337, (1978).
Brownlee, et al., Science, vol. 206, pp. 1190-1191, 1979.
Dixon, "A Reaction of Glucose with Peptides", Biochem. J., vol. 129, pp. 203-208, (1972).
Goodfriend, et al., "Antibodies to Bradykinin and Angiotensin: A Use of Carbodiimides in Immunology", Science, vol. 144, pp. 1344-1346, (1964).
Chen Jung S.
Huang John J.
Lovins Robert E.
Mezei Louis M.
Garber Stanley N.
O'Meara William R.
Phillips Delbert R.
Sherwood Medical Company
Upchurch Gregory E.
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