Optical: systems and elements – Holographic system or element – Having particular recording medium
Reexamination Certificate
2007-11-21
2010-10-12
Chang, Audrey Y (Department: 2872)
Optical: systems and elements
Holographic system or element
Having particular recording medium
C359S035000, C430S001000
Reexamination Certificate
active
07813016
ABSTRACT:
A harmonic holography (H2) technique and system that combines holography and nonlinear optics that enables holographic recording of 3D images with femtosecond framing time are provided. The H2technique records holograms with second harmonic (SH) signals scattered off specialized nanocrystals that are functionalized to label specific protein or other biomolecules in a living organism. The capability of generating second harmonic radiations is specific to materials with noncentrosymmetric crystalline structures only, and χ(2)vanishes for all other types of materials. Therefore, a sharp contrast is formed when particles of noncentrosymmetric structures are dispersed in a medium of other species, pumped at a fundamental frequency, and imaged at the second harmonic frequency. The new scheme described herein provides a sound basis for a new type of contrast microscopy with enormous potential in molecular biomedical imaging.
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Psaltis Demetri
Pu Ye
California Institute of Technology
Chang Audrey Y
Kauth, Pomeroy, Peck & Bailey LLP
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