Method of N-acylating peptide and proteins with diheteroatom sub

Details Method of N-acylating peptide and proteins with diheteroatom sub Method of N-acylating peptide and proteins with diheteroatom sub

1994-03-28

1996-11-05

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435130, 435132, 435193, 530402, 530404, 530406, C12P 2106, C12P 700, C12P 1100, C12N 910, C07K 113

Patent

active

055716890

ABSTRACT:
A method for acylating peptides and proteins with the CoA-ester of diheteroatom substituted C.sub.13 to C.sub.14 myristic acid analogs catalyzed by N-myristoyltransferase is presented. In the analogs, two non-adjacent methylene groups, which are normally at positions 3-13, are replaced with oxygen or sulfur atoms.

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