Method of MRI using avidin-biotin conjugated emulsions as a site

Details Method of MRI using avidin-biotin conjugated emulsions as a site Method of MRI using avidin-biotin conjugated emulsions as a site

1996-05-23

1998-07-14

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 9321, A61B 5055

Patent

active

057800103

ABSTRACT:
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.

REFERENCES:
patent: 5174737 (1992-12-01), Weiner et al.
patent: 5512294 (1996-04-01), Li et al.
patent: 5527528 (1996-06-01), Allen et al.
patent: 5571498 (1996-11-01), Cacheris et al.
patent: 5585112 (1996-12-01), Unger et al.
Urdal et al., "Tumor-associated Ganglio-N-Triosylceramide", Joural of Biological Chemistry, vol. 255, No. 21, pp. 10509-10516, (1980).

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