Method of monitoring therapeutic agent consumption

Chemistry: analytical and immunological testing – Nitrogen containing – Amine and quaternary ammonium

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436808, 436901, G01N 3348

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active

057767831

ABSTRACT:
Quantitative compliance markers and associated methods for monitoring patient compliance with medication prescriptions associated with compliance markers have been found to eliminate the need for specific quantitative relationships for each new drug tested. Such compliance markers and methods for monitoring patient compliance utilize pharmacologically inert substances, namely the weak acids benzodiazepines, or non-metabolizable substances in association with an underlying drug at a measurable dosage, so as to correlate compliance marker concentration with underlying medication concentration to determine amount of actual medication ingested.

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Balabanova, et al., Methadone distribution in blood, cerebrospinal fluid, urine and organ tissues, Embase No. 92091431, Austria 1991.
Nilsson et al., Effect of Urinary pH on the disposition of methadone in man, Embase No. 82171209, W. Germany 1982.

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