Method of monitoring the effect of Cathepsin S inhibitors

Details Method of monitoring the effect of Cathepsin S inhibitors Method of monitoring the effect of Cathepsin S inhibitors

2006-04-11

2006-04-11

Le, Long V. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S002000, C435S003000, C435S004000, C435S007200, C435S007210, C435S007230, C435S007240, C435S040500, C435S287200, C435S326000, C435S335000, C435S372100, C435S372300, C435S962000, C436S501000, C436S506000, C436S507000, C436S546000, C436S063000, C436S064000, C436S172000, C436S175000, C436S177000, C436S811000, C436S813000, C436S825000, C356S300000, C356S326000, C356S328000, C382S133000, C382S141000, C382S260000

Reexamination Certificate

active

07026132

ABSTRACT:
The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed subjects.

REFERENCES:
patent: 5919639 (1999-07-01), Humphreys et al.
patent: 5976858 (1999-11-01), Palmer et al.
patent: 6245904 (2001-06-01), Melms et al.
patent: 6495333 (2002-12-01), Willmann et al.
patent: WO 97/40066 (1997-10-01), None
patent: WO 99/58153 (1999-11-01), None
Nakagawa et al., “Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice”,Immunity(1999) 10:207-217.
Palmer et al., “Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors”,J. Med. Chem. (1995) 38:3193.
Riese et al., “Essential Role for Cathepsin S in MHC Class II-Associated Invariant Chain Processing and Peptide Loading”,Immunity(1996) 4(4):357-366.
Riese et al., “Cathepsin S Activity Regulates Antigen Presentation and Immunity”,J. Clin. Invest. (1998) 101(11):2351-2363.
Shi et al., “Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development”,Immunity(1999) 10:197-206.
Shi et al., “Role For Cathepsin F In Invariant Chain Processing And Major Histocompatibility Complex Class II Peptide Loading By Macrophages”,J. Exp. Med., vol. 191(7), pp. 1177-1185 (2000).
Chapman, “Endosomal Proteolysis And MHC Class II Function”,Curr. Op. Immunol., vol. 10, pp. 93-102 (1998).
Thurmond et al., “Identification Of A Potent And Selective Noncovalent Cathepsin S Inhibitor”,J. Pharmacol. Exp. Ther., vol. 308, pp. 268-276 (2004).
Villadangos et al., “Degradation Of Mouse Invariant Chain: Roles Of Cathepsins S And D And The Influence Of Major Histocompatibility Complex Polymorphism”,J. Exp. Med., vol. 186, No. 4, pp. 549-560 (1997).

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