Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-12-19
1997-04-08
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 792, G01N 3353
Patent
active
056186797
ABSTRACT:
Monoclonal antibodies and a method capable of detecting Bowman Birk inhibitor metabolites in a sample of body fluid or tissue are provided.
REFERENCES:
patent: 5053327 (1991-10-01), Brandon et al.
Billings et al., "Disbribution of the Bowman Birk protease inhibitor in mice following oral administration", Cancer Lett. 1992, 62, 191.
Brandon et al., "Monoclonal Antibody-Based Enzyme Immunoassay of the Bowman-Birk Protease Inhibitor of Soybeans", J. Agric. Food Chem. 1989, 37, 1192.
Brandon et al., "ELISA Analysis of Soybean Trypsin Inhibitors in Processed Foods", Adv. Exp. Med. Biol. 1991, 289, 321.
Brandon, D. L., "Antigenicity of Soybean Protease Inhibitors", Protease Inhibitors as Cancer Chemopreventive Agents, Plenum Press, New York, 1993, pp. 109-129.
Koch and Raleigh, "Radiolytic Reduction of Protein and Nonprotein Disulfides in the Presence of Formate: A Chain Reaction", Arch. Biochem. Biophys. 1991, 287, 75.
Lord et al., "Detection of Hypoxic Cells by Monoclonal Antibody Recognizing 2-Nitroimidazole Adducts", Cancer Res. 1993, 53, 5721.
Madar et al., "The Fate of the Bowman-Birk Trypsin Inhibitor from Soybeans in the Digestive Tract of Chicks", Comp. Biochem. Physiol. 1979, 62A, 1057.
Persiani et al., "Polylysine Conjugates of Bowman-Birk Protease Inhibitor as Targeted Anti-carcinogenic Agents", Carcinogenesis 1991, 12, 1149.
Yavelow et al., "Bowman-Birk Soybean Protease Inhibitor as an Anticarcinogen", Cancer Res. 1983, 43, 2454.
Kennedy Ann R.
Koch Cameron J.
Lord Edith M.
Wan Xingsheng
Scheiner Toni R.
Trustees of the University of Pennsylvania
University of Rochester
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