Drying and gas or vapor contact with solids – Process – Freeze-drying
Reexamination Certificate
2005-02-01
2005-02-01
Bennett, Henry (Department: 3749)
Drying and gas or vapor contact with solids
Process
Freeze-drying
C034S268000, C034S420000
Reexamination Certificate
active
06848196
ABSTRACT:
A method of monitoring a freeze-drying process in an apparatus (1) holding one or more samples (9) of a material to be freeze dried, comprises the steps of directing input radiation onto the sample (9), the input radiation forming output radiation by interaction with the sample (9); collecting at least part of the output radiation and leading the thus collected radiation to a radiation analyzer (11); and analyzing the collected radiation spectroscopically in the radiation analyzer (11) to obtain a measurement value of one or more freeze-drying parameters of the sample (9), such as the temperature of the sample (9) and/or the content of a solvent in the sample (9) and/or the structure of the sample (9).
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Bardat et al., “Moisture measurement: A new method for monitoring freeze drying cycles”, Journal of Parenteral Science and Technology, vol. 47, No. 6, 293-299.
Connelly et al., “Monitor Iyophilizaton with mass spectrometer gas analysis”, Journal of Parenteral Science and Technology, vol. 47, No. 2, 70-75.
AstraZeneca AB
Bennett Henry
O'Malley Kathryn S.
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