Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-05-09
2010-06-01
Padmanabhan, Sreeni (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S350000, C546S261000, C546S262000
Reexamination Certificate
active
07728013
ABSTRACT:
Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.
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Beigelman Leonid
Blatt Lawrence M.
Kossen Karl
Radhakrishnan Ramachandran
Seiwert Scott D.
Bendrick John
Intermune, Inc.
Jean-Louis Samira
Marshall & Gerstein & Borun LLP
Padmanabhan Sreeni
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